The research projects is focused on the identification of alteration of immunoregulatory patterns leading to allergic reaction to food. Our preliminary data suggests that allergic individuals are characterized by a variety of dysregulated immunological pathways including the acquisition of a clear survival advantage by key cell types. We will seek to evaluate the role of this Bcl-2 mediated event in allergy and the underpinning mechanism.
Relevance Area: Basic Research
Research Group:
Claudio Nicoletti, Miriam Durante, Denise Bonente, Tiziano Tamborrino