Breve curriculum vitae
2010 B.Sc in Biotechnology, University “Magna Graecia” of Catanzaro, Italy (graduation grade: 110/110)
2015 MSc (Licentiate) in Biology applied to Biomedicine at University of Pisa “β adrenergic system in proliferative retinopathies: a functional study”. Supervisor: Dr. Maurizio Cammalleri (graduation grade: 110/110 cum laude)
2019 Thesis for PhD degree in Molecular Medicine.at University of Siena, “UPARANT, a novel multitarget drug for neovascular and inflammatory ocular diseases” defended on April 2019. Supervisor Prof. Massimo Dal Monte.
May 2014 -Oct 2015 Scholarship, Department of Biology, University of Pisa, via San Zeno 31, 56127 Pisa, Italy. “Developement of transgenic animal model for functional studies”
Jan 2017-Dec 2017 Visiting Scholar Research at St Erik Eye Hospital, department of Clinical Neurosciences, Karolinska
Pubblicazioni e abstracts
List of Publication,Articles
Locri F., Dal Monte M., Aronsson M., Cammalleri M., De Rosa M., Pavone V., Kvanta A., Bagnoli P., André H. Uparant is an effective antiangiogenic in a mouse model of rubeosis iridis associated with proliferative retinopathy. Mol Med (Berl). 2019 Jun 26. (PMID: 31243519).
Cammalleri M, Dal Monte M, Locri F, Pecci V, De Rosa M, Pavone V, Bagnoli P.The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model. J Cell Mol Med. 2019 Jun 28. (PMID: 31251468)
Locri F., Cammalleri M., Pini A., Dal Monte M., Rusciano D., Bagnoli P. Further Evidence on Efficacy of Diet Supplementation with Fatty Acids in Ocular Pathologies: Insights from the EAE Model of Optic Neuritis. Nutrients. 2018 Oct 6;10(10). pii: E1447. (PMID: 0301197)
Locri F., Aronsson M., Beaujean O., Kvanta A., André H. Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis. J Vis Exp. 2018 Mar 8;(133) (PMID: 29578513)
Dal Monte M., Cammalleri M., Locri F., Amato R., Marsili S., Rusciano D., Bagnoli P. Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis. Nutrients. 2018 Mar 8;10(3). pii: E325 (PMID: 29517994)
Pisani F, Cammalleri M, Dal Monte M., Locri F., Mola M.G., Nicchia G.P., Frigeri A., Bagnoli P., Svelto M. Potential role of the methylation of VEGF gene promoter in response to hypoxia in oxygen-induced retinopathy: beneficial effect of the absence of AQP4. J Cell Mol Med. 2018 Jan;22(1):613-627 (PMID: 28940930)
Cammalleri M., Dal Monte M., Locri F., Marsili S., Lista L., De Rosa M., Pavone V., Rusciano D., Bagnoli P. Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System. J Diabetes Res. 2017; 2017:2904150 (PMID: 29464181)
Cammalleri M., Locri F., Catalani E., Filippi L., Cervia D., Dal Monte M., Bagnoli P. The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy. Front Cell Neurosci. 2017 Dec 12;11:395 (PMID: 29375312)
Cammalleri M., Dal Monte M., Locri F., Lardner E., Kvanta A., Rusciano D, André H., Bagnoli P. Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration. Nutrients. 2017 Sep 29;9(10). pii: E1079 (PMID: 28961167)
Beaujean O., Locri F., Aronsson M., Kvanta A., André H. A novel in vivo model of puncture-induced iris neovascularization. PLoS One. 2017 Jun 28;12(6):e0180235 (PMID: 28658313)
Cammalleri M., Locri F., Marsili S., Dal Monte M., Pisano C., Mancinelli A., Lista L., Rusciano D., De Rosa M., Pavone V., Bagnoli P. The Urokinase Receptor-Derived Peptide UPARANT Recovers Dysfunctional Electroretinogram and Blood-Retinal Barrier Leakage in a Rat Model of Diabetes. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3138-3148 (PMID: 28632880)
Cammalleri M., Dal Monte M., Locri F., Lista L., Aronsson M., Kvanta A., Rusciano D., De Rosa M.,Pavone V., André H., Bagnoli P. The Urokinase Receptor-Derived Peptide UPARANT Mitigates
Angiogenesis in a Mouse Model of Laser-Induced Choroidal Neovascularization. Invest Ophthalmol Vis Sc. 2016 May 1;57(6):2600-2611 (PMID: 27168367)
Dal Monte M., Rezzola S., Cammalleri M., Belleri M., Locri F., Morbidelli L., Corsini M., Paganini G.,Semeraro F., Cancarini A., Rusciano D., Presta M., Bagnoli P. Antiangiogenic Effectiveness of the
Urokinase Receptor-Derived Peptide UPARANT in a Model of Oxygen-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2392-4207 (PMID: 25766585)
Meeting Abstracts
- Locri F., Cammalleri M., Dal Monte M., De Rosa M., Pavone V., Bagnoli P. (2018) The urokinase- type plasminogen activator receptor system plays an important role in regulating inflammation in retinal degeneration. 69° Convegno Annuale della Società Italiana di Fisiologia, September 19- 21, Firenze, Italy.
- André H., Locri F., Aronsson M., Dal Monte M., Cammalleri M., Bagnoli P., De Rosa M., Pavone V., Kvanta A. (2018) Cenupatide is an effective antiangiogenic in a mouse model of rubeosis iridis associated with neovascular glaucoma. ARVO Annual Meeting, April 29-May 3, Honolulu, HI, USA.
- Locri F., Aronsson M., Cammalleri M., Dal Monte M., Bagnoli P., De Rosa M., Pavone V., Kvanta A., André H. (2018) UPARANT is an effective antiangiogenic in a mouse model of rubeosis iridis. 14th ISOPT Clinical, March 1-3, Tel Aviv, Israel.
- Locri F., Beaujean O., Aronsson M., Kvanta A., André H. (2017) A novel in vivo model of puncture- induced iris neovascularization. XX Annual Meeting of the European Association for Vision and Eye Research (EVER), September 27-30, Nice, France.
- Dal Monte M., Amato R., Locri F., Cammalleri M. (2017) Nebivolol acts as a beta3-adrenergic receptor agonist in a mouse model of oxygen-induced retinopathy. XX Annual Meeting of the European Association for Vision and Eye Research (EVER), September 27-30, Nice, France.
- Dal Monte M., Cammalleri M., Locri F., Marsili S., Lista L., Mancinelli A., Pisano C., De Rosa M., Pavone V., Rusciano D., Bagnoli P. (2017) Diabetes-induced retinal complications in rat models of diabetes: efficacy of the urokinase receptor-derived peptide UPARANT in counteracting retinal damages. 68° Convegno Annuale della Società Italiana di Fisiologia, September 6-8, Pavia, Italy.
- Pisani F., Cammalleri M., Dal Monte M., Locri F., Mola M.G., Nicchia G.P., Frigeri A., Bagnoli P., Svelto M. (2017) Methylation-dependent control of HIF-1/VEGF axis in oxygen-induced retinopathy: beneficial effect of absence of Aquaporin-4. 68° Convegno Annuale della Società Italiana di Fisiologia, September 6-8, Pavia, Italy.
- Rusciano D., Dal Monte M., Locri F., Cammalleri M., Bagnoli P. (2017) Efficacy of a new food supplement in a murine model of atrophic AMD. ARVO Annual Meeting, May 7-11, Baltimore, USA.
- Marsili S., Cammalleri M., Locri F., Dal Monte M., Rusciano D., Pavone V., De Rosa M., Bagnoli P. (2017) The Urokinase Receptor-Derived Peptide UPARANT as a Novel Therapy to Recover High-Glucose Associated Retinal Damage in Spontaneously Diabetic Torii Rats. ARVO Annual Meeting, May 7-11, Baltimore, USA.
- Rusciano D., Cammalleri M., Locri F., Dal Monte M., Bagnoli P. (2017) Efficacy of a New Food
- Supplement in a Murine Model of Optic Neuritis. 13th AOPT, February 16-19, Firenze, Italy
- Rusciano D., Bagnoli P., André H., Dal Monte M., Cammalleri M., Locri F., Aronsson M., Kvanta A., Lista L., Pavone V., De Rosa M. (2016) The uPAR/FRP antagonist UPARANT shows anti- angiogenic and antinflammatory properties in rodent models of retinal neovascular disease. ARVO Annual Meeting, Seattle, USA.
- Pisani F., Cammalleri M., Dal Monte M., Locri F., Nicchia G.P., Frigeri A., Bagnoli P., Svelto M.
- (2016) AQP4 regulates transcriptional activation of VEGF in response to hypoxia through HIF-1 Binding Site methylation in Oxygen-Induced Retinopathy. 67° Convegno Annuale della Società Italiana di Fisiologia, September 21-23, Catania, Italy.
